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The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well end in an increase in methadone plasma concentrations, which could induce most likely fatal respiratory despair. Moreover, discontinuation of concomitantly applied cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also bring about an increas